MyBioSource.com's PERK, phosphorylated (Thr980) (PKR-like ER Resident Kinase) is a Rabbit monoclonal antibody. The PERK, phosphorylated (Thr980) (PKR-like ER Resident Kinase) Antibody was generated using EIF2AK3, PEK, and PERK as the antigen. It reacts with Rat, and Drosophila/Arthropod. This antibody has been shown to work in applications such as: ELISA, and Western Blot.
Description
PERK, an eIF2 alpha kinase, is a transmembrane protein resident in the endoplasmic reticulum (ER) membrane and couples ER stress signals to translation inhibition. ER stress increases the activity of PERK, which then phosphorylates eIF2 alpha, resulting in reduced translation. PERK-deficient mice have defects in pancreatic beta cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress. PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain. Phosphorylation of PERK at Thr980 can serve as a marker for its activation status